Philippe Valet Selected Research

Apelin

5/2022	Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth.
11/2021	Apelin expression deficiency in mice contributes to vascular stiffening by extracellular matrix remodeling of the aortic wall.
1/2020	Plasma Apelin and Risk of Type 2 Diabetes in a Cohort From the Community.
1/2019	Apelin affects the mouse aging urinary peptidome with minimal effects on kidney.
1/2019	The apelin/APJ system as a therapeutic target in metabolic diseases.
1/2018	Apelin administration improves insulin sensitivity in overweight men during hyperinsulinaemic-euglycaemic clamp.
1/2018	Chronic apelin treatment improves hepatic lipid metabolism in obese and insulin-resistant mice by an indirect mechanism.
1/2018	Therapeutic Benefit and Gene Network Regulation by Combined Gene Transfer of Apelin, FGF2, and SERCA2a into Ischemic Heart.
1/2018	The exerkine apelin reverses age-associated sarcopenia.
11/2017	Pharmacological targeting of apelin impairs glioblastoma growth.

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Philippe Valet Research Topics

Disease

30	Obesity 01/2022 - 05/2003
22	Insulin Resistance 01/2021 - 04/2005
17	Neoplasms (Cancer) 05/2022 - 04/2011
17	Inflammation (Inflammations) 11/2021 - 07/2006
8	Body Weight (Weight, Body) 01/2019 - 02/2007
6	Type 2 Diabetes Mellitus (MODY) 01/2020 - 06/2010
6	Breast Neoplasms (Breast Cancer) 01/2019 - 02/2011
6	Fibrosis (Cirrhosis) 01/2018 - 12/2007
6	Hyperinsulinism (Hyperinsulinemia) 02/2014 - 04/2005
5	Metabolic Diseases (Metabolic Disease) 01/2019 - 02/2011
4	Hypoxia (Hypoxemia) 06/2017 - 07/2010
4	Hyperglycemia 06/2016 - 10/2005
4	Glucose Intolerance 08/2012 - 03/2007
3	Noonan Syndrome (Female Pseudo-Turner Syndrome) 01/2021 - 03/2012
3	Hypertrophy 01/2019 - 06/2010
3	Overweight 01/2018 - 04/2010
3	Cardiomegaly (Heart Hypertrophy) 01/2017 - 06/2010
2	Fatty Liver 03/2022 - 05/2008
2	Cardiovascular Diseases (Cardiovascular Disease) 11/2021 - 01/2017
2	Prostatic Neoplasms (Prostate Cancer) 02/2021 - 01/2016
2	Weight Loss (Weight Reduction) 01/2021 - 06/2008
2	Melanoma (Melanoma, Malignant) 01/2020 - 01/2016
2	Thrombosis (Thrombus) 12/2019 - 02/2016
2	Sarcopenia 01/2019 - 01/2018
2	Myocardial Infarction 01/2018 - 06/2017
2	Heart Failure 01/2018 - 09/2012
2	Ventricular Dysfunction 01/2013 - 09/2012
2	Hyperphagia (Overeating) 08/2012 - 03/2007
1	Colorectal Neoplasms (Colorectal Cancer) 05/2022
1	Non-alcoholic Fatty Liver Disease 03/2022
1	Diabetes Mellitus 01/2022
1	Neoplasm Metastasis (Metastasis) 02/2021
1	Arthritis (Polyarthritis) 01/2021

Drug/Important Bio-Agent (IBA)

34	ApelinIBA 05/2022 - 04/2005
20	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 10/2005
13	Insulin (Novolin)FDA Link 01/2018 - 04/2005
11	LipidsIBA 11/2021 - 02/2007
10	AdipokinesIBA 01/2022 - 04/2005
8	CytokinesIBA 01/2022 - 12/2007
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2003
6	Peptides (Polypeptides)IBA 01/2019 - 11/2011
5	CholesterolIBA 01/2022 - 04/2010
5	Messenger RNA (mRNA)IBA 02/2021 - 01/2011
5	CollagenIBA 01/2021 - 01/2014
4	Triglycerides (Triacylglycerol)IBA 01/2021 - 02/2012
4	EnzymesIBA 01/2020 - 03/2004
4	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 02/2012
4	Nonesterified Fatty Acids (NEFA)IBA 01/2019 - 04/2014
4	Apelin ReceptorsIBA 11/2017 - 06/2010
4	Peptide Hydrolases (Proteases)FDA Link 01/2016 - 02/2011
4	lysophosphatidic acidIBA 01/2014 - 12/2007
3	AminesIBA 02/2021 - 08/2007
3	Tyrosine (L-Tyrosine)FDA Link 01/2021 - 03/2012
3	Blood Glucose (Blood Sugar)IBA 01/2018 - 04/2010
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 06/2017 - 12/2007
3	Interleukin-6 (Interleukin 6)IBA 01/2014 - 04/2011
3	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2013 - 03/2004
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 09/2011 - 02/2010
2	ChemokinesIBA 02/2021 - 05/2008
2	Oxidoreductases (Dehydrogenase)IBA 02/2021 - 08/2007
2	human AOC3 proteinIBA 02/2021 - 12/2010
2	Pharmaceutical PreparationsIBA 01/2021 - 12/2007
2	Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA 01/2021 - 03/2012
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021 - 02/2010
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 06/2010
2	Hormones (Hormone)IBA 11/2018 - 07/2011
2	DNA (Deoxyribonucleic Acid)IBA 01/2017 - 07/2010
2	LipopolysaccharidesIBA 02/2014 - 05/2008
2	Glucagon-Like Peptide 1 (GLP 1)IBA 02/2014 - 10/2008
2	Drinking WaterIBA 01/2014 - 04/2010
2	2,4-dinitrofluorobenzene sulfonic acidIBA 01/2014 - 03/2011
2	LeptinIBA 01/2014 - 05/2008
2	3- (4- (4- ((1- (2- chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acidIBA 01/2014 - 12/2007
2	Conditioned Culture MediaIBA 09/2013 - 12/2007
2	Monoamine Oxidase (MAO)IBA 01/2013 - 03/2004
2	Nitric Oxide Synthase (NO Synthase)IBA 05/2012 - 02/2010
2	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 11/2011 - 03/2011
2	Phosphotransferases (Kinase)IBA 07/2011 - 03/2011
2	benzylamineIBA 12/2010 - 04/2010
2	Phospholipids (Phosphatides)FDA LinkGeneric 09/2008 - 12/2007
2	Lysophosphatidic Acid ReceptorsIBA 09/2008 - 12/2007
2	Connective Tissue Growth FactorIBA 09/2008 - 12/2007
1	Calcibiotic Root Canal SealerIBA 05/2022
1	Liver X ReceptorsIBA 03/2022
1	HMGB1 Protein (HMG1)IBA 03/2022
1	CreatinineIBA 01/2022
1	ProgranulinsIBA 01/2022
1	cathepsin SIBA 11/2021
1	Leukocyte Elastase (Neutrophil Elastase)IBA 11/2021
1	Chemokine ReceptorsIBA 02/2021
1	Interleukin-9 (Interleukin 9)IBA 01/2021
1	F8 monoclonal antibodyIBA 01/2021
1	Single-Chain AntibodiesIBA 01/2021
1	AlarminsIBA 04/2019
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2019
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2019
1	neuromedin UIBA 01/2019

Therapy/Procedure

6	Therapeutics 05/2022 - 02/2010
1	Endurance Training 01/2021
1	Drug Therapy (Chemotherapy) 01/2019